Founder Metrics - Contribution Detail Report - listing the founders of a group of animals, showing the %contribution to the group, the %founder alleles retained, and the likelihood that each founders genes have only been passed down to at most one member of the group
Founder Metrics Contribution Detail Report - Matrix with founders in columns and group members in rows, giving the %contribution of each founder to each descendant
Metrics of genetic diversity can be computed for any group of individuals within the pedigree data set. Typically such a group defines the 'current population', or a subset of current population that is available for breeding. In addition, you choose the depth of ancestry of the group members to be analysed.
PedScope provides various ways to analyse the relationship between any group of individuals and their founders (where a founder is defined as an ancestor that has neither sire nor dam within the ancestry under study), and can compute the following important values:
You can tabulate all the founding ancestors of a group, including columns for:
You can then drill down to display a founder contribution matrix that gives the %contribution of each founder to each descendant within the group, or to view the genome uniqueness for each founder with respect to each descendant (i.e., the probability that the given descendant is the only member of the current population that has inherited the respective founder's genes). To compute these metrics PedScope performs a gene drop analysis for the individuals under study and their ancestors .
For further information please see the Reports section of the User Guide.
1. Lacy, RC. Analysis of founder representation in pedigrees: Founder equivalents and founder genome equivalents. Zoo Biology 8:111-124, 1989.
2. Boichard, D, Maignel L, and Verrier, E. The value of using probabilities of gene origin to measure genetic variability in a population. Genetics Selection Evolution, 1997; 29(1): 5-23.
3. MacCluer, JW, VandeBerg JL, Read B and Ryder OA. Pedigree analysis by computer simulation. Zoo Biology 5, 147/160, 1986.